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Angaben zum Forschungsprojekt
Evaluation neuropsychologischer Trainingsprogramme nach intensivierter onkologischer Therapie (ENTOR): Kontrolliert-randomisierte Vergleichsstudie computergestützter versus konventioneller Trainingsprogramme
Ziele und Fragestellungen:
Verbundprojekt / Gefördertes Projekt / Studie
Bundesministerium für Bildung und Forschung (BMBF)
Deutsche Rentenversicherung Bund
Evaluation of neuropsychological training programmes following intensified oncological therapy: a controlled randomised comparative study of computer-aided training versus conventional programmes
Although the neurotoxicity of many antineoplastic substances has been known for long, only little empirical investigation was carried out regarding neuropsychologic deficits following oncological therapies. While initially research was concentrated mainly on patients having undergone high-dose chemotherapies, recent studies now also reveal and document the possibility of neuropsychologic impairments arising with 'conventional' chemotherapies. Often empirical studies show little correlation between the results of formal neuropsychological testing and the patients' subjective perception; this necessitates the integration of psychosocial measuring instruments into a differentiated study design. Up to date, there is no single study on the efficiency of neuropsychological rehabilitation programmes for patients with neoplasies not affecting the CNS.
Objectives and topics:
This study is designed to investigate the short- and medium-term effects of two specific neuropsychological interventions against a control group without any specific treatment. In addition to a differentiated comparison of the two trainings with regard to their effects on the level of neuropsychologic functions, correlations with various psychosocial parameters will also be investigated.
Design of the Study:
Within the framework of a controlled and randomised study, patients from two target groups (breast cancer patients after adjuvant chemotherapy and patients with malignant system diseases after haematopoetic stem cell therapy) are examined for neuropsychologic impairment by means of a special screening; in case of existence of deficits they are assigned to one of the two intervention groups (group training led by a specialized occupational therapist or computer-aided single training) or to the control group without any specific treatment (N=210).
Dates of measurement: t1 = hospitalisation; t2 = end of rehabilitation phase; t3 = 6 months after end of rehabilitation.
Evaluation is carried out using neuropsychological parameters focussing on processes of attention, memory, the patients' subjective assessment of their cognitive performance in everyday life, psychic state, life quality, coping with the disease, somatic disease variables and relevant sociodemographical data.